Laboratory medicine

Laboratory medicine

Friday, April 15, 2016

GeneXpert MTB/RIF Assay: How it works

GeneXpert MTB/RIF assay is a rapid diagnosis test of Tuberculosis (TB) and drug resistance.  It is revolutionizing TB control with aids in prompt diagnosis and treatment (selection of appropriate TB regimen).
GeneXpert MTB/RIF assay is a nucleic acid amplification (NAA) test which simultaneously detects DNA of Mycobacterium tuberculosis complex (MTBC) and resistance to rifampin (RIF) (i.e. mutation of the rpoB gene) in less than 2 hours. In comparison, standard cultures can take 2 to 6 weeks for MTBC to grow and conventional drug resistance tests can add 3 more weeks.
This system integrates and automates sample processing, nucleic acid amplification, and detection of the target sequences.
Fig. Gene Xpert box

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