VITROS® 350 Chemistry System: VITROS® MicroSlide Technology

VITROS® MicroSlide Technology

High-quality results, minimal operator interventions, exceptional ease of use and 95% reportable result efficiency with innovative layered dry slide technology

Providing fast, accurate results is a necessity—even for small labs—with growing pressure to reduce errors and cut costs in the midst of increased demands and significant staffing shortages. The VITROS® 350 System is a compact chemistry system designed to be efficient, dependable, and, above all, easy to use as a primary, STAT, or backup system.

VITROS® MicroSlide Technology is one of the 5 enabling technologies that power the transformational performance of our VITROS® diagnostic instruments in labs around the world.

Working priniciple:

VITROS® MicroSlide Technology offers an entire integrated test environment on a thin piece of film. Spreading, masking, scavenger, and reagent layers are discretely combined on one postage-stamp-sized slide to produce first-class precision and accuracy. When plasma, serum, urine, or cerebrospinal fluid come into contact with these dry chemical layers, a spectral reaction occurs, which can be measured by the system. This layered dry slide technology enables separate reaction domains—maximizing each step for exceptional assay performance.

Read more at: https://www.orthoclinical.com/en-in/solutions-products/chemistry-immunodiagnostic/chemistry/vitros-350

Fig. VITROS® 350 Chemistry System
Picture credit: www.lshospital.zj.cn

DCA Vantage Analyzer: Features and benefit

DCA Vantage Analyzer

Drive diabetic patient compliance with trusted, clinically proven results

One system does it all. Detect* and manage diabetes with HbA1c or diagnose early kidney disease with albumin:creatinine ratio (A:C) testing using Siemens Healthcare's DCA Vantage^® Analyzer. No sample or reagent preparation is required.

• Add a 1µL fingerstick sample for HbA1c or a 40 µL urine sample for A:C to applicable test cartridge.
• Scan test cartridge barcode.
• Load cartridge into analyzer.
• The analyzer does the rest.

Results are generated in minutes allowing for immediate consultation during the patient visit.

Monitor glycemic control and diabetes complications using an analyzer designed to make consultations easier. Fast, actionable test results enable you to determine the effectiveness of a treatment plan, make therapeutic adjustments with confidence, and be more certain whether patients are complying with your recommendations. 

 

Monitor glycemic control

• HbA1c from a small (1 µL) whole blood sample in 6 minutes
• Flexible reporting of HbA1c% (NGSP, JDS, and Mono-S units) and IFCC (mmol/mol)
• Reporting of HbA1c results as Estimated Average Glucose values* in the same units (mg/dL) that patients’ home glucose meters display
• HbA1c patient trending graphs can be viewed or printed

Detect early kidney disease

• Albumin, Creatinine, and Albumin-to-Creatinine (A:C) ratio from a urine specimen in 7 minutes to report a quantitative protein status with automatic creatinine adjustment
• Onboard GFR calculator indexes kidney function

Improve workflow in the office or clinic

• Self-contained cartridges facilitate easy, walkaway operation after sample loading
• No sample or reagent preparation required
• Bar-code scanner for safer and faster patient/operator ID entry
• Review results on-screen or generate a hard copy report to minimize transcription errors in the office
• Convenient local storage of up to 4,000 onboard records with powerful sorting capabilities
• Automatically upload results to a PC via a USB flash drive to reduce manual logging and save time
• Minimal maintenance requirements with automatic reminders to alert you when maintenance is due

Read more: http://www.healthcare.siemens.com/point-of-care/diabetes/dca-vantage-analyzer/features-benefits

Fig. DCA vantage barcode
Credit: www.healthcare.siemens.com

Protein estimation : Qualitative and quantitative

Proteins are the most abundant biomolecules, constituting more than 50% of the dry weight of the cell. They are known to perform many different biological functions.  Qualitative and quantitative estimation of proteins in biological fluids is based on the physico-chemical properties of proteins.

DENATURATION OF PROTEINS

In each type of protein, the three dimensional structure is essential for its biological function.  A protein in the biologically active form is termed as the native protein and the native state is called “optimum” state. The disruption of the three dimensional structure is called denaturation.  On denaturation, the primary structure remains intact.  It is an all or none phenomenon and does not cause any alteration in the quantity of protein present.

CHARACTERISTICS OF DENATURATION

Following are the major changes involved in denaturation:

1.       Increase in the viscosity due to uncoiling

2.       Change in the isoelectric pH

3.       Changes in the properties of solubilization and crystallization

4.       Loss of biological activity.

(Read more at: http://edusanjalbiochemist.blogspot.com/2015/12/qualitative-and-qualitative-estimation.html)

Fig. Test tube showing Biuret test positive